Department of Neurochemistry

Department of Neurochemistry

Department of Neurochemistry




Head: Martin Horák, PhD.

Tel.: +420 241 062 725


The Department of Neurochemistry studies molecular mechanisms that regulate the function of glutamate receptors in the mammalian central nervous system. We also aim to develop novel pharmacological compounds that act on glutamate receptors for the treatment of cognitive decline caused by neurodegeneration. Our experimental approach includes microscopy, biochemistry, and electrophysiology in cultured hippocampal neurones and human fibroblasts derived from patients with neurodegenerative diseases. Our long-term goal is to develop “personalised” compounds for treating specific neurodegenerative conditions including Alzheimer disease.

Deputy Head:
Oksana Forostyak, MD., PhD.

Research Scientists:
Oksana Forostyak, MD, PhD.
Martin Horák, PhD.

Ph.D. students:
Marharyta Kolcheva, MSc.
Ing. Štěpán Kortus, MSc.
Katarína Lichnerová, MSc.
Kristýna Skřenková, MSc.

Dominika Dušková

OP VVV PharmaBrain,

Regulation of the trafficking and function of GluN3A-containing NMDA receptors in mammalian neurones
GAČR, 18-04329S, 2018-2020

Role of transmembrane domain in transport and function of NMDA receptors
GAUK, 468217, 2017-2019

Novel hybrid compounds in the cognitive decline caused by neurodegeneration
GAČR, 16-08554S, 2016-2018

National Institute of Mental Health, Klecany

Biomedical Research Center, Hradec Kralove

Neuroscience Research Institute, Seoul National University College of Medicine, Republic of Korea